QUESTION 1 Match the following features with the correct type of inheritance. (1

Question

QUESTION 1

Match the following features with the correct type of inheritance.

(1 mark each)

Autosomal recessive inheritance

Autosomal dominant inheritance

X-linked recessive inheritance

X- linked dominant inheritance

A male with the trait passes it on to all his daughters and none of his sons; every affected person has a least one parent with the trait.

Transmission can be from fathers to daughters and sons, or from mothers to daughters and sons; all affected individuals have at least one affected parent.

If a mother is a carrier of the trait she will appear unaffected; the trait may reappear in her sons.

The trait can disappear from a branch of the pedigree but reappear in later generations; there are approximately equal numbers of affected females and males.

4 points

  

QUESTION 2

If the following pedigree is for an autosomal recessive characteristic, which individuals can ONLY be heterozygous for the trait (i.e. Aa only)? (Select all that apply)

Please note that if an incorrect selection is chosen, you will receive a penalty.

I-1

I-2

II-1

II-2

II-3

II-4

II-5

II-6

II-7

III-1

III-2

III-3

5 points   

QUESTION 3

If the following pedigree is for an X-linked recessive characteristic, which individuals can ONLY be carriers of the trait?(Select all that apply)

Please note that if an incorrect selection is chosen, you will receive a penalty.

I-1

I-2

II-1

II-2

II-3

II-4

II-5

III-1

III-2

III-3

III-4

III-5

IV-1

IV-2

      -       a.       b.       c.       d.   

Autosomal recessive inheritance

  

Autosomal dominant inheritance

X-linked recessive inheritance

X- linked dominant inheritance

a.

A male with the trait passes it on to all his daughters and none of his sons; every affected person has a least one parent with the trait.

b.

Transmission can be from fathers to daughters and sons, or from mothers to daughters and sons; all affected individuals have at least one affected parent.

c.

If a mother is a carrier of the trait she will appear unaffected; the trait may reappear in her sons.

d.

The trait can disappear from a branch of the pedigree but reappear in later generations; there are approximately equal numbers of affected females and males.

1 4 1 2

Explanation / Answer

A. Autosomal recessive inheritance : The trait can disappear from a branch of the pedigree but reappear in later generations, there are equal numbers of affected females and males.

B. Autosomal dominant inheritance : Transmission can be from fathers to son and daughters or mothers to son and daughters, all affected individuals have at least one affected parent.

C. X linked recessive inheritance : A male with the trait passes it to on to all his daughters and none of his sons, every affected person has at least one parent with the trait.

D. X linked dominant inheritance : If a mother is a carrier of the trait, she will appear unaffected, the trait may reappear in her sons.

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