DIPRIVAN Injectable Emulsion is available in ready to use 20 mL infusion vials,
ID: 128048 • Letter: D
Question
DIPRIVAN Injectable Emulsion is available in ready to use 20 mL infusion vials, 50 mL infusion vials, and 100 mL infusion vials containing 10mg/mL of propofol
Dose recommendations:
Although dose must be adjusted according to the results of suitable lab tests, the following dose schedules may be used as guidelines:
AnesthesiaInduction
<55 years: 2-2.5 mg/kg until onnset
>55 years: 1-1.5 mg/kg until onset
Maintenance
<55 years old: 0.1-0.2 mg/kg/min IV >55 years old: 0.05-0.1 mg/kg/min IV
The hospital has infusion equipment capable of control up to 0.01 mL.If a patient 45 years old and 195 pounds is treated with Diprivan , evaluate the following:
A) What is the IUPAC name for propofol?
B) Identify the main chemical functionalities present in propofol and what possible impact they could have in the blood plasma pH
C) Based on the content of this course, what is the expected solubility of propofol in water?
D) Why Diprivan is an emulsion?
E) Research/Investigate and briefly describe the main mechanism of action of propofol.
F) When used as recommended calculate the following:
If the induction occurs in approximately 30 seconds what is the flow required to administer the recommended dose?
If the procedure last for 2 hours, what is the maintenance flow required for the patient
At the end of the procedure how my mg of propofol were used?
How many mL of Diprivan were injected during the whole procedure?
Explanation / Answer
Per Chegg policy, a maximum of 4 questions can be answered at a stretch, hence, answers to questions to the best possible extent.
What is the IUPAC name for propofol?
The IUPAC name of propofol is 2,6-Diisopropylphenol or 2,6-di(propan-2-yl)phenol
E) Research/Investigate and briefly describe the main mechanism of action of propofol.
It is an IV anesthetic with very rapid action with short life period. It is used in IV form for induction and sedation of anesthesia during major procedures of surgeries.
F) When used as recommended calculate the following:
If the induction occurs in approximately 30 seconds what is the flow required to administer the recommended dose?
The hospital has infusion equipment capable of control up to 0.01 mL.If a patient 45 years old and 195 pounds is treated with Diprivan, evaluate the following:
Assuming that a patient is 45 years old and weighs 195 pounds or 88.5 kg.
For anesthesia induction, the dose required is
(<55 years: 2-2.5 mg/kg until onset)
2 x 88.5 to 2.5 x 88.5 = 177 to 221.25 mg.
Therefore, the required dose is 177 to 221.25 mg.
The volume of drug required is 17.7 to 22.13 mL. (10 mg of drug equals 1 mL). this dose should be administered in 30 seconds.
The flow rate set would be 35.4 to 44.25 mL per minute.
If the procedure lasts for 2 hours, what is the maintenance flow required for the patient?
For this patient, the maintenance flow rate required is 0.1-0.2 mg/kg/min IV as he is less than 55 years of age.
Therefore, the flow rate set would be,
= 531 to 1062 mg.
As 10 mg equals 1 mL of the drug.
The set flow rate would be 53.1 to 106.2 mL/hour.
At the end of the procedure how my mg of propofol was used?
The total amount of drug administered to the patient at the end of the procedure is
Amount used for induction + maintenance dose
= 177 to 221.25 mg + 531 to 1062 mg.
= 708 to 1283.25 mg.
Or 70.8 to 128.33 mL.
How many mL of Diprivan were injected during the whole procedure?
The total mL of drug injected was 70.8 to 128.33 mL.
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