PLEASE ANSWER ALL PARTS Chapter 11 Virus-modified exosomes have been proposed fo
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Question
PLEASE ANSWER ALL PARTS
Chapter 11
Virus-modified exosomes have been proposed for targeted nucleotide delivery to cells as shown below.
A. Describe the molecular composition of virus-modified exosomes.
B. Compare the composition to a typical eukaryotic cell membrane and describe the function of the different molecules.
C. Describe what you deliver with this molecules and how it would function.
Viral and cellula components selective inc ration Virus-modified exosomes "stuffed" with selected viral and/or cellular components MVB Virus-modified exosomes Cytoplasm EBVExplanation / Answer
A. 1.Virus modified exoxomes are specialized form of nano sized vesicles calles exosomes can incorporate and transport functional RNA into target cells serves as attractive alternative.
2. Exosomes are small vesicles secreted from cells that participate in intercellular communication events.
3. In cancer, exosomes have linked to tumor growth, progression and metastasis.
B. 1.On virus(EVB) exposure, infecte naive B-cells release highlly specific EVB modified exosomes.
2. Latent membrane protein 1 is expressed on virus infected cell membrane. Which causes proliferation programm and B cell immortalization and contribute viral spread. immune evasion.
C. 1. Specialised form of nano-sized lipid vesicles can incorporate and transport functional RNA into target virus infected cells.
2. Most pluricellular organisms sustain exosome based communication via inter cellular exchange of mRNA and miRNA between cells.
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