No Service 8:40 PM * 100%. X CHEM 107 Case Study 3 Questi... 1. What is the mini
ID: 1030551 • Letter: N
Question
No Service 8:40 PM * 100%. X CHEM 107 Case Study 3 Questi... 1. What is the minimum lethal dose of dimethyl mercury for humans? How is this compound classified? 2. Explain in 2-3 sentences how Karen Wetterhahn was poisoned with dimethyl mercury. 3. What were the initial and later symptoms of mercury poisoning that she experienced, and what was the timing of each? 4. What did the analysis of her brain after death reveal about the damage caused by the dimethyl mercury? 5. From the analysis of Karen Wetterhahn's blood, what was the concentration of mercury in her blood (g/L)? 6. How much total mercury (in mg) was in her blood and in her entire body? 7. What did the analysis of Karen Wetterhahn's hair reveal about the poisoning? Open With Print
Explanation / Answer
1 = lethal dose has been determined to be less than 0.1ml (about 1-2 drops)
2 = Wetterhahn’s latex gloves offered no protection from the dimethylmercury, an especially dangerous organic mercury compound. So it got into her body and she died.
3 =
acute elemental (metallic) mercury poisoning include:
Tremors
Emotional changes
Insomnia
Weakness
Muscle atrophy
Twitching
Headaches
Disturbances in sensations
Changes in nerve responses
Performance deficits on tests of cognitive function.
Higher exposures may result in kidney effects, respiratory failure and death.
4 = the methylmercury is primarily responsible for the neurological alterations present in humans.
It is believed that the mechanisms are related to the toxic increase in reactive oxygen species (ROS). Oxidative stress is associated with the etiology of neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease
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