Mark each statement below TRUE or FALSE and give reasons. Credit given ONLY if y

Question

Mark each statement below TRUE or FALSE and give reasons. Credit given ONLY if your reasoning is correct. a. Gluconeogenesis is upregulated during long periods of exercise because blood [glucose] decreases. b. A mutation in Adenylate Cyclase would most likely decrease the rate of Gluconeogenesis in liver. c. Taking a drug that inhibits muscle lactate dehydrogenase would have no effect on ATP production under anaerobic conditions (ex: during intense exercise) d. A mutation in PFK-1 that reduces its affinity for ATP would always result in an increase in glycolysis. e. Forcing the expression of Glucose-6-Phosphatase would raise blood glucose levels when fasting.

Explanation / Answer

A- True. Because as glucose is depleted it is necessary to maintain the glucose level. Gluconeogenesis maintains the level of glucose from non carbohydrate sources like pyruvate.

B- true

Adenylate cyclase is one of the most important enzymes in the activation of Gluconeogenesis pathway and mutation will likely to decrease the rate of Gluconeogenesis

3 - Flase

Because under anaerobic conditions the lactate dehydrogenase interconverts lactate to pyruvate and hence the ATP production. So inhibition of LDH will in turn affect the production of ATP during anaerobic conditions.

D- False.

PFK-1 mutation that reduces it's affinity for ATP would result in decrease Glycolysis as it is one of the most critical steps of finding Glycolysis.

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