We are screening for inhibitors of a particular important metabolic enzyme that

Question

We are screening for inhibitors of a particular important metabolic enzyme that appears to affect the drought tolerance of specific strains of wheat. Which of the following statements about the types of enzyme inhibitors that we might find is TRUE? Select the best answer.

Competitive inhibitors decrease the apparent KM of the enzyme but have no effect on Vmax.

Noncompetitive inhibitors increase the apparent KM of the enzyme but have no effect on Vmax.

Uncompetitive inhibitors can either increase or decrease Vmax but have no effect on the KM of the enzyme

Competitive inhibitors decrease the apparent KM of the enzyme but have no effect on Vmax.

Explanation / Answer

In competitive inhibition, the KM increases but have no effect on Vmax.

In non competitive inhibition, Km decreases but Vmax decreases

uncompetivie decrease both Km and Vmax

higher concentrations of substate can overcome the inhibition and hence this is also incorrect.

All the four statements are incorrect.

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