The sequence below is the sequence of the human beta-globin..... GenBank Sequenc

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The sequence below is the sequence of the human beta-globin.....

GenBank Sequence Repository-Human beta-GIobin Gene I) Purpose And Procedure In this exercise, you will dissect the sequence of the human beta-globin gene, to reveal which portions of the gene are used to encode the beta-globin protein and where certain critical regulatory sites are. You will also answer questions regarding whether a particular change in the DNA sequence is expected to change the level of activity in the gene's protein. The genetic code table and a figure showing the structures and charges of the different amino acids are provided to help you answer these questions. II) The Structure And Sequence Of The Human Beta-Globin Gene The sequence below is the sequence of the human beta-globin gene from chromosome 11. This particular version of the beta-globin gene's sequence is from the National Center for Biotechnology Information's GenBank database. GenBank is the repository for all published DNA sequences, from all the species whose DNA has been or is being sequenced. As you can see, this is a sequence of 2052 nucleotides. It includes the promoter region of the beta-globin gene, the coding sequence and some of the sequence that borders the gene on both sides. The arrangement of the promoter region, exons and introns in the human beta-globin gene is depicted in the figure below. The different elements of the gene's structure correspond to the nucleotides in the sequence as follows: Pro = promoter region, nucleotides 1-103 El = exon 1, nucleotides 104-245 I1 = intron 1. nucleotides 246-375 E2 = exon 2, nucleotides 376-598 I2 = intron 2, nucleotides 599-1448 E3 = exon 3, nucleotides 1449-1709 To help you decipher the information presented read the notes on the left side of the GenBank entry, which indicate the essential aspects of the sequence. Here's a glossary, so you know what the terms mean: source = the entire sequence in this entry-all 2052 bases

Explanation / Answer

1 Answer:

Human beta globin is nothing but the globin protein which comprise of most of the area of the haemoglobin the beta globin is usually encoded by the human beta globin gene and the portion which is encoded by the beta globin gene is the human chromosome 11 because if its not encoded the mutation will takes place on this chromosome and will lead to the disorder such as thalassemia and other genetic disorder which will also include sickle cell anaemia. so chromosome 11 is the certain critical regulatory site where there might be the chances of the occurances of the mutation.

So the change in the DNA sequence will change the activity of the gene protein because as the mutation in the DNA takes place we can say that some mutation will have no effect on the gene protein but some mutation will affect the gene protein which will help to confirm whether the gene is active or not. because gene will help to form the protein molecule which helps to carry out marious important functions in the cells.

which include

gene activation

insertion and deletion

gene duplication etc.

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