Your grandfather has been told he has high cholesterol and has been given one of

Question

Your grandfather has been told he has high cholesterol and has been given one of the statins to bring it down. He asks you if you can think of any reason that he should not double the dose so that it will reduce blood cholesterol faster. What do you tell him?

A) Yes, statins block the reabsorbtion of bile, effectively blocking the absorbtion of cholesterol.

B) Yes, statins decrease the amount of LDL receptors on the surface of intestinal mucosal cells, thereby decreasing cholesterol uptake into the blood.

C) Yes, statins increase the amount of LDL receptors on the surface of blood vessels increasing the internalization of cholesterol into cells and clearing the blood.

D) No, at high levels, statins have a stimulatory effect on HMG-CoA reductase rather than an inhibitory effect.

E) No, some cholesterol synthesis is essential. Cholesterol is essential for proper functioning of cell membranes and for precursors for bile salts and steroid hormones.

Explanation / Answer

Answer:

First we will see what are the statins so statins are the HMG-CoA inhibitors this HMG-CoA is very helpful for the production of the cholestrol in the body. so the person who is at the high risk of having high cholestrol will be given statins which will block the HMG-CoA by which the cholestrol is produced.

But if we increase or double the dose of statins it will result in low cholestrol level in the body so some cholestrol systhesis is necessary for the body because it is helpful to form the cell membrane and various of the harmones and may also be helpful for the metabolisis of the body. so from the above question the option (E) is suggested to the patient.

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