Mark as ReadReply P21-activated kinase 1 (PAK) is a member of the PAK famity who

Question

Mark as ReadReply P21-activated kinase 1 (PAK) is a member of the PAK famity whose role is to maintain several functions in the cell as a whole. PAK, specifically, has a few important jobs such as growth factor signaling, cytoskeletal remodeig, cei prororation, and gene transruten. From an article that Iread soet ve been able to get better look at this PAK fany and understand how this focus could beuseu for caror reseath. As bsines come down to brd with r specte site. PAK1werks in prosoroyution of Se substate r, oor for tobind, whet,, ncrease or decrease production. This sgnal mienJe has been a focus becase pasees with cancer have a higeranourt ofhee PAK1 and been determined that the reason forth because of the production of the tumor where the cancer lies. PAKI works in relation with GTPases which are lke switches during cell proliferation In many different cancers PAK1 can be found in great abundance and is crucial inancogenesis. weh the p ence of PAKs apoptoss is ihbted, therefore cels that uteathy kinled, thus cancerous celis muiply

Explanation / Answer

This look good. But still you have to give some clear idea how to target this protein to decrease the effect of cancer or actual mechanism under goes here. PAK1 contains an autoinhibitory domain that suppresses the catalytic activity of its kinase domain. Generally IPA-3 binds with PAK1 of regulatory domain region to prevent GTPase activity. If any mutation undergoes in this region it turns into autoPhosphorylation events leads to continuous kinase activation it leads to activation of number of pathways especially MAPK pathway involved in cell cycle..

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