A titratable group is in the active site of an enzyme and must be protonated for

Question

A titratable group is in the active site of an enzyme and must be protonated for the enzyme to function. Assume that the group has a pKa of 6.5 and that the activity is proportional to the fraction of molecules in the protonated state. Which of the following are true?

A.)At pH 9.0 close to 100% of the enzyme molecules are active.

B.)At pH 9.0 close to 100% of the enzyme molecules are inactive.

C.)At pH 6.5 the enyzme is 50% active.

D.)At pH 6.8 the enzyme is 66.6% inactive.

E.)At pH 7.2 there are about 5 inactive enzymes for every active enzyme.

Explanation / Answer

It is given that the activity is proportional to the fraction of molecules in the protonated state.

The true statement is E.

E.) At pH 7.2 there are about 5 inactive enzymes for every active enzyme.

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