A tissue engineering approach to treating liver failure involves the implantatio

Question

A tissue engineering approach to treating liver failure involves the implantation of
membrane bound aggregates of liver cells. In designing these aggregates, it is important
to ensure that all the cells receive enough oxygen to survive. A hepatocyte aggregate
150um in diameter is encapsulated in a layer of gel and placed in well mixed media.
Determine the maximum thickness of the gel layer that would result in an oxygen
concentration of at least 6e-08 mol/ml everywhere in the aggregate. Assume the
diffusivity of oxygen in the gel is 2e-05cm2/s and that the bulk concentration is 1e-7
mol/ml. The maximum uptake rate of oxygen by the cells is 3.5e-8 mol/ml/s. Assume
zero-order kinetics, spherical shape gel and aggregates, and steady state conditions.
Cells in aggregate (150um)

Explanation / Answer

No answer text found in this record.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.