How to improve the GREEN CHEMISTRY of this lab. Please go into depth, THANK YOU!

Question

How to improve the GREEN CHEMISTRY of this lab. Please go into depth, THANK YOU!

The Synthesis of NMP, A Fluoxetine Precursor Goal is to synthesize NMP 1.) KO'Bu NaBHs 2.)Oxalic Acid Week 1 Week 2 NMP Salt Week 1 Add 1.0 grams of 3-dimethylaminopropiophenone hydrochloride to a 250 mL beaker fitted with a magnetic stirbar (use a large one). Add 5 mL of water and stir until the salt is dissolved. While stirring, add 3 mL of 10% NaOH (aq) to form the free base of the amine which appears as a milky solution. Add enough 95% EtOH (~5 mL) to dissolve the free base to provide a clear solution. Add 0.2 grams of NaBH4 to the solution in 3 portions. (CAUTION: Hydrogen gas (toxic) will evolve form the solution). Continue stirring for 15 minutes then add 6.0 M HCl to destroy the excess NaBH4 (CAUTION: Add the acid dropwise until the solution is not fizzing as vigorously). Once the fizzing stops, the NaBH4 has been destroyed. (should take about 3 mL of 6.0 M HCI). Once the NaBH4 is quenched, basify the solution (pH > 10) using 10% NaOH to form the free base of the amine. If this is not done, the SNAr next week will not work. This should take about 8 mL of base. Use pH paper to check the pH. Add the cooled reaction mixture to a separatory funnel. Add 10 mL of ether shake well (REMEMBER TO VENT) and separate the organic layer. Extract the aqueous layer (the bottom layer) once more with 10 mL of ether. Combine the organic extracts, dry with MgSo4 then boil off the excess solvent in the fume hood with instructor approval. Store the product in a vial labeled with your initials and class information in your drawer

Explanation / Answer

In the step 1 instead of sodium borohydride, if we use diborane it could be the greener way to synthesize the final compound.

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