Use the following diagram from a Nature Review article that outlines +RNA viral

Question

Use the following diagram from a Nature Review article that outlines +RNA viral replication to help you answer the activity questions on the next page.

3.

a. Which protein complex is doing the process shown in “A”?

b. Why can this happen as soon as the genome enters the cell?

Pro-apoptotic Anti-apoptotic ffocts Shut off host cell Shut off host cell (cap Polyprotein nteractions between the vinus and the cel cycle ral replication complex dsRNA (atency) strand (goniome 3 3 5 3 Cell lysis Veal ogrees Nature Reviews Microbiology 3, 765-776 (October 2005) dol: 10.1038/nrmicro1284

Explanation / Answer

a) IRES protein is developed by Viral Protein(VPg) Viral genomic RNA has a viral protein(VPg) at its 5 end instead of methylated nucleotide cap structure contains internal ribosome entry site allowing the translation of polyproteins. VPG protien is removed from viral RNA and translated to polyprotien.

b) The capsid of virus contains VPg proteins as soon as the virus cell enters the host it causes conformational changes in the virus particle causing the breakdown of capsid and releases of VPg proteins and these VPg proteins are responsible of producing of viral genome from positive strand and later into polyprotiens.  

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