please give explanations where you can, thanks!! Match the T cell cytokine with
ID: 96272 • Letter: P
Question
please give explanations where you can, thanks!!
Match the T cell cytokine with its appropriate effector function. 1) IFN- gamma 2) IL-2 3) IL-4 4) IL-5 5) IL-13 6) IL-17 7) IL-21 8) IL-17 and IL-22 9) TGF- beta and IL-10 ______Involved in B-cell proliferation ______Along with CD40L, helps activate macrophage ______Promotes further Th2 differentiation ______Released in the absence of infection ______Recruits and activates eosinophils ______Recruits and activates neutrophils ______Involved in T cell proliferation Increases MHC expression ______Released early in infection ______Promotes further Th1 differentiation ______Stimulates mucus production by goblet cells ______Induces production of antimicrobial peptides by epithelial cellsExplanation / Answer
1. IFN- gamma : Increases MHC expression
and released early in infection
Promotes the further diferentiation of Th1 cells
Because it induces the expression of Class II MHC molecules during the event of a bacterial or a viral infection
2. IL-2 : Involved in T-cell proliferation
Because the interleukin 2 (IL-2) helps the regulatory T cells to grow.
3. IL-4: Promotes further Th2 differentiation
Because the IL-4 cells help in the differentiation of helper T cells to the Th2 cells. These Th2 cells get further activated by IL-4 by a positive feedback mechanism. Due to this, more IL-4 cells are released which further induce and promote the differentiation of Th0 to Th2
4. IL-5 : Involved in T-cell proliferation
Recruits and activates eosinophils
Recruits and activates neutrophils
Because these IL-5 cells are secreted by the helper T cells to bring abou th differntiation of the activated T-cells into the cells which secrete the immunonoglobulins.
6. IL-13: Involved in B-cell proliferation
7. IL- 17: Stimulates mucus production by the goblet cells
Because it activates the mucin gene.
8.IL-21: Along with CD40L, helps activate macrophage
Because it kills the cells which get infected by a virus or the cells which become cancerous in nature
9. IL-17 and IL-22: Induces the production of antimicrobial peptides by epithelial cells.
Because they act on keratinocytes together, to produce peptides which act against the microbes.
10- TGF beta and IL-10: Released in the absence of infection
Because they act to suppress autoimmunity during which the self cells of body are recognised as the antigens. The foreign antigens during infection are not needed to trigger autoimmune conditions. Autoimmunity is triggered buggered because the immune cells of body fail to differentiate between the self and non self antigens thus, they attack the body's own cells. This reaction is avoided by the release of TGF beta and IL-10
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