7) Suppose you are attempting the separation of three compounds (A, B, and C) by

Question

7) Suppose you are attempting the separation of three compounds (A, B, and C) by column chromatography on silica gel. You start by running a number of TLC’s in order to find the best solvent system for the separation. The results are summarized in the table below.

a) How polar are the three compounds: low, medium, or highly polar (please estimate)?

b) What would be the result of a column chromatographic separation if the column chromatography was to be performed in the following eluents: a) hexane, or b) ethyl acetate. Please explain.

Solvent Rf for A Rf for B Rf for C Hexane .10 .00 .00 Toluene .20 .00 .04 Diethyl Ether .51 .18 .28 Ethyl acetate .81 .45 .60

Explanation / Answer

a) A   highly polar

C        medium polar

B        low polar ]

b) Ethyl acetate is a polar sol so will attract most polar .medium polar .low polar so better solvent for doing this exp

Hexane can show only highly polar and not others

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