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What is teratogen? For which of the chemicals you will use in this experiment ha

ID: 946307 • Letter: W

Question

What is teratogen? For which of the chemicals you will use in this experiment have teratogenic effects been observed in toxicity studies? (... just in case this is not part of your answer to Q4!) Which halogen is most reactive in EAS reactions? The exact structure of the active "I^+" species in this experiment is not known. What are two possibilities for its structure? Why must this experiment be performed at an ice bath temperature? What might the major product be it the reaction was performed at a higher temperature? Why should you be careful not to leave your reaction Bask in the ice bath tor more than 10 minutes? Why is sodium thiosulfate used in this experiment? This experiment uses absolute ethanol and 95% ethanol. Describe the difference between the two and how each is used.

Explanation / Answer

7) Fluorine is most reactive in electrophillic aromatic substitution reactions since it is more electronegative and can act as a good electrophile.

8) Structure for I : I+ and I3+

9) Since phenols are very reactive towards EAS, the reaction is carried out in an ice bath. This allows for monoiodinated product to be formed. If it is carried out at higher temperature, polyiodinated product is most likely to be observed.

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