3. Examine each of the pedigrees below. Give the most likely inheritance pattern

Question

3. Examine each of the pedigrees below. Give the most likely inheritance pattern for each. Defend your answer by writing a brief explanation as to why your choice is better than other choices?

a.

b.

c.

Explanation / Answer

A) X-linked recessive - we note only males are affected and there is no Male->male transmission, suggestive of X-recessive. B) Autosomal recessive - we note the disease skipping two generations (rules out dominant) and we note male->male transmission of the recessive gene (if you track the disease-free members who pass on the gene), ruling out X-linkage. C) Autosomal dominant - we note the disease in each generation (more likely dominant than recessive) and we note equal involvement of male and female progeny. Hope that helps! Jonathan

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