All amino acids have two ionizable functional groups: an ?-amino group (average

Question

All amino acids have two ionizable functional groups: an ?-amino group (average pKa of 9.4) and an ?-carboxylic acid group (average pKa of 2.2). Aspartic acid has an ionizable side chain (R group) with a pKa of ~3.8. One of the possible ionization states of aspartic acid is shown below.

Question 4 of 34 All amino acids have two ionizable functional groups: an -amino group (average pKa of 9.4) and an -carboxylic acid group (average pKa of 2.2). Aspartic acid has an ionizable side chain (R group) with a pKa of -3.8. One of the possible ionization states of aspartic acid is shown below Mapd H3N-CH-C-OH CH OH At what pH would the above structure be the predominant ionization state? Note: Consider the ionization state of all three of the functional groups. pH1.5 Scroll down for more of this question The protonated form of the R group of aspartic acid is shown in the structure above. The ratio of the protonated form to the charged (deprotonated) form depends on the pKa of the R group and the pH of the solution. Select all the pH values at which the charged form of the R group would predominate 2.3 3.8 7.0 11.6 Hint Previous Give Up & View Solution O Check Answer Next Exit

Explanation / Answer

as R group is acidic in nature   solution should be basic to remove the H+ carboxy group. so at pH 11.6

the charged form of R group is predominant.

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