All amino acids have two ionizable functional groups: an -amino group (average p

Question

All amino acids have two ionizable functional groups: an -amino group (average pKa of 9.4) and an . carboxylic acid group (average pKa of 2.2). Aspartic acid has an ionizable side chain (R group) with a pKa of 3.8. One of the possible ionization states of aspartic acid is shown below. H3N CH -C-OH CH2 OH At what pH would the above structure be the predominant ionization state? Note: Consider the ionization state of all three of the functional groups. pH = | Select answer Scroll down for more of this question. 1.5 3.9 5.6 7.0 8.9 The proton 10.4 of aspartic acid is shown in the structure above. The ratio of the

Explanation / Answer

At lesser pH this structyre will dominate

Answer: 1.5

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isoelectric point = (2.2+3.8)/2 = 3

at pHabove 3 it will dominate

Answer: 3.8,7.0,11.3

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