The pedigree shows the inheritance of a very rare, completely penetrant autosoma

Question

The pedigree shows the inheritance of a very rare, completely penetrant autosomal recessive disorder. Note that the couple in generation IV are currently expecting their first child (indicated by the "?") 11) What is the probability the child will be affected by the disorder? 12) What is the probability the child will be a carrier (i.e., heterozygous for the causative mutation)? 13) What is the probability the child will be neither affected nor a carrier (i.e., that he/she will be homozygous wild-type)?

Explanation / Answer

1) if both parents are carrier (Aa) than there is only 25 % chances of their child being affected.If one parent is carrier (Aa) and other is normal(AA) than their will be no child affected and if both the parents are normal (AA)than no child will be affected.

2) the probability is 50% if both the parents are carrier and if one parent is carrier and other is normal than also it will be 50% but if both are normal than there will be no carrier

3) if parents are carrier than 25 % child will be homozyous wild type and if one parent is carrier and other is normal than 50 % will be homozygous wild type.if both parents are normal than 100% child will be homozygous wild type.

a indicated the affected allel and A indicate the normal allel.

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