The pedigree shown below depicts the inheritance patterns of a certain genetic d

Question

The pedigree shown below depicts the inheritance patterns of a certain genetic disease. Assume that this disease is rare in the population.

a. Indicate the most likely mode of inheritance for this disease. Explain your reasoning.

b. If this represents the inheritance of albinism, which occurs in 1/10,000 in the general population, determine the probability that the first child (II?1) is a carrier and marries a carrier from the general population and that they have an affected child? (Assume that population is in equilibrium.)

Explanation / Answer

If the parents doesnot have the disease but three of the kids have it means it is autosomal recessive and the mother and father are carrier of the gene but doesnot show the feature.

in this case of autosomal inheritance there is probability of 1/2 child getting affected

which is clearly visible from the pedigree as 3 out of 6 child jave disease. In this one gene from mother and father both gets inherited and causes disease

1/2 is the probability as discussed in case of these autosomal recessive inheritance

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