Shown below is the cDNA sequence for Homo sapiens delta hemoglobin. Analyze this

Question

Shown below is the cDNA sequence for Homo sapiens delta hemoglobin. Analyze this sequence and answer the following questions:

(1): Does this sequence contain intron? If yes, mark all introns in the sequence and label them

(2) Does it contain a regular polyA signal? If it does, mark and label the polyA signal sequence.

(3). If it contains a biologically valid peptide coding region, mark and label the coding sequences.

GACACTTTCTTCTGACATAACAGTGTTCACTAGCAACCTCAAACAGACACCATGGTGCATCTGACTCCTG

AGGAGAAGACTGCTGTCAATGCCCTGTGGGGCAAAGTGAACGTGGATGCAGTTGGTGGTGAGGCCCTGGG

CAGATTACTGGTGGTCTACCCTTGGACCCAGAGGTTCTTTGAGTCCTTTGGGGATCTGTCCTCTCCTGAT

GCTGTTATGGGCAACCCTAAGGTGAAGGCTCATGGCAAGAAGGTGCTAGGTGCCTTTAGTGATGGCCTGG

CTCACCTGGACAACCTCAAGGGCACTTTTTCTCAGCTGAGTGAGCTGCACTGTGACAAGCTGCACGTGGA

TCCTGAGAACTTCAGGCTCTTGGGCAATGTGCTGGTGTGTGTGCTGGCCCGCAACTTTGGCAAGGAATTC

ACCCCACAAATGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCTAATGCCCTGGCTCACAAGTACC

ATTGAGATCCTGGACTGTTTCCTGATAACCATAAGAAGACCCTATTTCCCTAGATTCTATTTTCTGAACT

TGGGAACACAATGCCTACTTCAAGGGTATGGCTTCTGCCTAATAAAGAATGTTCAGCAAAAAAAAAAAAA

AAAAAAAAAAAAAA

Explanation / Answer

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

AAAAAAAAAAAAAAAAAAAAAAAAAAA poly A site, presence of chain of Adenine at the terminal.

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