A) Odd-number fatty acids are initially oxidized by the same pathway as even-num

Question

A) Odd-number fatty acids are initially oxidized by the same pathway as even-number fatty acids. For odd-number fatty acids, the two products are . . .

Odd-number fatty acids are initially oxidized by the same pathway as even-number fatty acids. For odd-number fatty acids, the two products are .. O acetyl-CoA; propionyl-CoA O succinyl-CoA; propionyl-CoA O succinyl-CoA; acetyl-COA The three carbon product of odd-number fatty acid oxidation is further metabolized into succinyl-CoA. What is the fate of this product? O O O Enters directly into an amino acid synthesis pathway. Enters the citric acid cycle. Shuttled into the mitochondrial matrix for electron transport. Incorrect.

Explanation / Answer

Odd numbered fatty acids are oxidized by the same path way as even number fatty acids. For odd numbered fatty acids, the two products are-

acetyl-CoA and propionyl-CoA

The three carbon product of odd numbered fatty acid oxidation is further metabolized into succinyl-CoA. The fate of this product is:

Enters citric acid cycle

Firstly, propionyl-CoA is carboxylated using a bicarbonate ion into D-stereoisomer of methylmalonyl-CoA, in a reaction that involves a biotin co-factor, ATP, and the enzyme propionyl-CoA carboxylase. The bicarbonate ion's carbon is added to the middle carbon of propionyl-CoA and it forms D-methylmalonyl-CoA. The D conformation is enzymatically converted into the L conformation by methylmalonyl-CoA epimerase, then it undergoes intramolecular rearrangement. This is catalyzed by methylmalonyl-CoA mutase (B12 acts as a coenzyme) to form succinyl-CoA. The succinyl-CoA formed can then enter the citric acid cycle.

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