49. RIMONABANT (antagonist of cannabinoid receptors) was withdrawn from the mark

Question

49. RIMONABANT (antagonist of cannabinoid receptors) was withdrawn from the markets due to a. Lack of efficiency b. Addictive properties c. Hallucinations d. An increase in incidence of depression and suicidal thoughts e. Heart valve pathology 50. Mice with deletion of both copies of CBI gene (cannabinoid receptor 1) tend to die earlier than their normal control littermates due to a. Heart disease b. Cancers c. Obesity d. Muscle Wasting e. A variety of unclear causes 51. One of the components in anti-obesity drug Contrave (naltrexone bupropione), developed by Orexigen is currently approved as a. Anti-migraine medication b. Thyroid gland stimulator c. Smoking cessation aid d. Anti-constipation agent e. Anti-ADHD medication 52. Victoza (Liraglutide) is so expensive (S160/day) because a. It is cutting edge drug b. It is a relative long peptide that has to be synthesized and modified for longer half-life c. It only as injection form by one-time use pens and cannot be converted to is available cheaper pill-based medicine d It is new drug, so the company has to price it higher in order to recover the costs of its e. All of the above 53. Which of newest weight-loss aids caused a protest letter being signed by 750 physicians being sent to FDA: a) Aspire Assist b) vBLOC c) gastric balloons d) Victoza. e) Pramlintide and Metreleptin peptide combo 54: Pro-inflammatory physiological condition which increases in adipose tissue along with an increase in average size of adipocyte is called a) Hyperplasy b) Metaplasy c) Hypoxia d) Oxidation e) Macroscopy

Explanation / Answer

49.d. A cannabinoid receptor antagonist, were used against obesity and was withdrawn from the market due to the side effects they produced which were depression and suicidal tendencies.

50.d. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity.

51.c.Contrave is a combination of two previously approved drugs that have been observed to reduce appetite : bupropion, often prescribed for depression and smoking cessation under the brand names Welbutrin and Zyban, and naltrexone (Vivitrol), which is primarily used to fight alcohol and opioid dependence.

52.e.

53.a. The AspireAssist is a new, FDA-approved weight loss solution for people with obesity. Unlike many other weight loss procedures, it’s non-surgical and reversible.

54.a Hyperplasy is the enlargement of an organ or tissue caused by an increase in the reproduction rate of its cells, often as an initial stage in the development of cancer.

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