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1) When insulin binds the insulin receptor, the IRS protein: phosphorylates the

ID: 932148 • Letter: 1

Question

1)

When insulin binds the insulin receptor, the IRS protein:

phosphorylates the insulin receptor

binds to the phosphorylated beta-chains of the insulin receptor

binds the G-alpha subunit

is not recruited to the receptor complex until Grb2 is associated

2)

Elevated levels of orotic acid can be clinically diagnostic for defects in which of the following pathways?

DNA replication

purine synthesis

purine salvage

pyrimidine synthesis

phosphorylates the insulin receptor

binds to the phosphorylated beta-chains of the insulin receptor

binds the G-alpha subunit

is not recruited to the receptor complex until Grb2 is associated

Explanation / Answer

1) binds to the phosphorylated beta-chains of the insulin receptor

2) pyrimidine synthesis