Arrange the sequence of reactions that occur in the conversion of pyruvate to ac

Question

Arrange the sequence of reactions that occur in the conversion of pyruvate to acetyl-CoA in the correct order: 1) The anion of the hydroxyethyl group attacks one sulfur of the disulfide in lipoic acid, and the resulting intermediate is oxidized to an acetyl thioester. 2) FAD is reduced to FADH2, while the two thiols of reduced lipoic acid are reoxidized back to a disulfide. 3) FADH2 is oxidized by NAD+. 4) Thiamine pyrophosphate decarboxylates pyruvate to yield hydroxyethyl-TPP. 5) The thioester derived from lipoic acid transfers its acetyl group to CoA.

Explanation / Answer

The sequence for the conversion of pyruvate to acetyl-CoA in the order would be;

4) Thiamine pyrophosphate decarboxylates pyruvate to yield hydroxyethyl-TPP.

1) The anion of the hydroxyethyl group attacks one sulfur of the disulfide in lipoic acid, and the resulting intermediate is oxidized to an acetyl thioester.

5) The thioester derived from lipoic acid transfers its acetyl group to CoA.

2) FAD is reduced to FADH2, while the two thiols of reduced lipoic acid are reoxidized back to a disulfide.

3) FADH2 is oxidized by NAD+.

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