Arrange the events of glycogen synthesis in the proper order. 1) The receptor di

Question

Arrange the events of glycogen synthesis in the proper order. 1) The receptor dimerizes. 2) Proteins, such as IRS-1, are recruited to the phosphorylated tyrosine domain of the receptor. 3) Autophosphorylation of the intracellular domain takes place. 4) Insulin binds to the insulin receptor. 5) IRS-1 is phosphorylated, which then activates phosphoinositide 3-kinase. 6) Protein kinase B is activated. 7) Phosphatidylinositol 4,5-bisphosphate is converted to phosphatidylinositol 3,4,5-trisphosphate. 8) Protein kinase B phosphorylates glycogen synthase kinase 3, inactivating it.

Explanation / Answer

Insulin Signaling pathway

Steps

4,1,3,2,5,7,6,8

4. Insulin binds to the insulin receptor

1. The receptor dimerizes.

3. Autophosphorylation of the intracellular domain takes place.

2. Proteins, such as IRS-1, are recruited to the phosphorylated tyrosine domain of the receptor

5 IRS-1 is phosphorylated, which then activates phosphoinositide 3-kinase.

7 Phosphatidylinositol 4,5-bisphosphate is converted to phosphatidylinositol 3,4,5-trisphosphate

6 Protein kinase B is activated

8 Protein kinase B phosphorylates glycogen synthase kinase 3, inactivating it.

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