Bisphenol A (BPA) is widely used as a building block in polymer synthesis and is

Question

Bisphenol A (BPA) is widely used as a building block in polymer synthesis and is found in the polycarbonate hard plastics of reusable drink containers, DVDs, cell phones, and other consumer goods. Bisphenol A is reported to have estrogenic activity, and its widespread occurrence in our environment is a potential concern.

Choose all the suggestions that correctly describe biochemical experiments that could be done to compare the activity of bisphenol A with that of its estradiol, its structural relative.

Select all that apply.

1. Check whether BPA can substitute estrogens in cells that bear mutations affecting estrogen synthesis.

2. Check for competitive or synergistic effects of coadministration of BPA and estradiol.

3. Compare the effects on transcription of estradiol and bisphenol A in estrogen-responsive cells.

4. Look directly for binding of radiolabeled BPA to receptors for estrogens and related hormones.

5. Compare physical properties of estrogens and BPA, such as solubility, rate of diffusion, three-dimensional molecular structure.

Explanation / Answer

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