A 7-month-old female is born with an inherited deficiency of CD59 on her red blo

Question

A 7-month-old female is born with an inherited deficiency of CD59 on her red blood cells. As a result of her deficiency, her red blood cells are continuously lysed, her urine appears red, and she suffers from hemolytic anemia. Under normal circumstances, which complement component(s) would CD59 directly bind to prevent cell lysis of red blood cells? A. C3bBb B. C3a and C5a C. C5b678 D. Factor H E. C3b The C4-binding protein (C4BP) acts to inhibit complement by displacing C2a from the C4b2a complex. Why is C4BP important for complement regulation? A. Because it prevents initial activation of the alternative pathway on human cells B. Because it prevents initial activation of the lectin pathway on pathogen surfaces C. Because it helps the complement system distinguish "self" from "non-self" D. Because it allows rapid formation of the other C3 convertase (C3bBb) on pathogen surfaces

Explanation / Answer

ANS) 1. According to above-given problem Under normal circumstances among all complement systems, Factor H would directly bind to prevent cell lysis of red blood cells. Therefore Ans is D) Factor H, Because factor H is associated with genetic disorders. And for a Hemolytic uremic syndrome or Hemolytic Anemia, Factor H is responsible.

2) C4BP is important for complement regulation because it is a protein, which involved in the complement system, and where it acts as inhibitor. It prevents initial activation of the lectin pathway on pathogen surface and a number of bacterial and fungal pathogens capture human C4BP, which allows them to establish infection.Therefore Ans is B).It prevents initial activation of the lectin pathway on pathogen surface

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