Answer the following questions based upon a tripeptide sequence of the following

Question

Answer the following questions based upon a tripeptide sequence of the following amino acids Serine-Alanine-Glutamate a) What is the overall charge on the most abundant tripeptide species at neutral pH? b) At physiological pH, for each of the amino acids, is the side chain (R group) hydrophobic, polar but uncharged, positively charged, or negatively charged? c) What is the overall charge of the most abundant tripeptide below pH 1.0? d) What is the overall charge of the most abundant tripeptide at pH 11.5? e) What type of intermolecular attractions could the side chains of the amino acids make with the water?

Explanation / Answer

For the tripeptide Serine-Alanine-Glutamate,

a) The overall charge on the most abndant species at neutral pH (pH 7) is -1.

b) At physiological pH the side chain is negatively charged.

c) Overall charge of tripeptide at pH 1 would be +1

d) The overal charge f tripeptide at pH 11.5 would be -2

e) The type of intermolecular attraction existing between the side chain of the amino acids and water would be H-bonding.

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