Assume that the following polypeptide sequence folds into an alpha helix. Which
ID: 89961 • Letter: A
Question
Assume that the following polypeptide sequence folds into an alpha helix. Which of the following statements is TRUE?
TCLAGSVKMAIVTCALIT
The online system says the second option is true, can you explain to me why? or is the online system wrong and is the first option the answer?
The NH group of the leucine (L) would hydrogen bond to the CO group of a valine (V).
The NH group of the leucine (L) would hydrogen bond to the CO group of an alanine (A).
There would be a disulfide bond in the helix.
Both the first and third answers are true.
Both the second and third answers are true.
Explanation / Answer
The correct option is:
The NH group of the leucine (L) would hydrogen bond to the CO group of a valine (V).
Explanation:
In the alpha helix, the hydrogen bonds are formed between carbonyl oxygen and amine hydrogen groups of four amino acid residues away. In the given peptide leucine makes hydrogen bonding with 4th residue which is valine. Disulfide bonds are seen in tertiary structures and not in secondary structures such as alpha helices.
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