Assume that the following polypeptide sequence folds into an alpha helix. Which

Question

Assume that the following polypeptide sequence folds into an alpha helix. Which of the following statements is TRUE?

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The online system says the second option is true, can you explain to me why?

The NH group of the leucine (L) would hydrogen bond to the CO group of a valine (V).

The NH group of the leucine (L) would hydrogen bond to the CO group of an alanine (A).

There would be a disulfide bond in the helix.

Both the first and third answers are true.

Both the second and third answers are true.

Explanation / Answer

When the following polypeptide sequence given above folds,

The true statements about the folding would be,

The NH group of the leucine (L) would hydrogen bond to the CO group of an alanine (A).

Here, the leucine and alanine are both hydrophobic in nature and thus, folding ensures the hydrophobic part of peptide is inside. This makes the hydrophobic ends of leucine and alanine come close and the amide NH of leucine forms a hydrogen bond with the C=O of the alanine easily.

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