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In cellular signaling, one of the important \"tags\" attached to proteins are ph

ID: 89691 • Letter: I

Question

In cellular signaling, one of the important "tags" attached to proteins are phosphates. Proteins that add phosphates are called kinases. In general, phosphorylation activates proteins.

Imagine there is a cyclin dependent kinase that is required for progression from G1 to S phase. A researcher isolates a cell with a version of this kinase that is normal, except it cannot perform the phosphorylation reaction.

What do you think would be the consequence of this mutation on the cell? Explain your answer--there are many possibilities.

Explanation / Answer

A cell lacking a functional kinase that performs phosphorylation can have different ramification.

The mutation can either arrest the cell in G1 phase of the kinase phosphorylates proteins involved in cell cycle progression.

the mutaion can cause the cell to bypass G1/S checkpoint if the kinase causes activation of an inhibitor protein.so cell in this case be ON for S-phase and M- phase as well.

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