PART 4: LUMINESCENT BACTERIA During your summer months, to escape the heat of Da

Question

PART 4: LUMINESCENT BACTERIA During your summer months, to escape the heat of Davis, you work with a group of scientists at the North Pole to study the bacterium This is that lives in dark icy waters. Your colleagues have found that during certain of the year, large populations of E. lumines cen glow. While you were away at school, times signal peptide that when your colleagues identified a External signal Molecule mRNA PROTEIN Gene Circuit senal Peptide Regulation Components: Signal Transcription mRNA (peptide) Factors Sequencel Open Reading Regulatory Frame Active Protein GB- glows introduced to a population of E Luminescent in the lab, will cause the bacterium to start glowing. Here are the notes they have written for you to bring you up to speed. The signal peptide is produced by E Luminescent. The signal peptide can then exit the cell and enter a neighboring E. Thus, overtime, an entire population of E. Lumines. cent will come into contact with the signal peptide. Upon contact with the signal peptide. the bacteria a protein Glow Bright (GB). The production of GB can be up- regulated by self-production of the signal peptide.

Explanation / Answer

The glucagon like peptide-1 receptor (GLP-1R) belongs to family B of the Fact protein-coupled receptor superfamily and is a target for treatment of type 2 diabetes. Family B G protein-coupled receptors contain a putative N-terminal signal peptide, but it's role in receptor Synthesis and trafficking are unclear. Further, the signal peptide is not cleaved in at least one family member.

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