which are the following true regarding Levinthal\'s Paradox Which are the follow
ID: 894151 • Letter: W
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which are the following true regarding Levinthal's Paradox Which are the following true regarding Levinthal's Paradox: This was a thought experiment Levinthal noticed that because of the very large number of degrees of freedom in an unfolded polypeptide chain, the molecule has an astronomical number of possible conformations. For example, a polypeptide of 100 residues will have 99 peptide fl bonds, and therefore 198 different phi and psi bond angles Therefore if a protein were to attain its correctly folded configuration by sequentially sampling all the possible conformations, it would require a time longer than the age of the universe to arrive at its correct native conformation The "paradox* is that most small proteins fold spontaneously on a millisecond or even microsecond time scale The paradox can be resolved if partially correct intermediates are retained during the protein folding process The paradox refers to the fact that most proteins require chaperones to fold.Explanation / Answer
Correct option is 1st and 2nd
Levinthal's paradox is a thought experiment which relates the theory of protein folding. There is a large number of degrees of freedom in polypeptide chain, so its has number of possible conformations. So, if a protein has to attain a correct folded configuration by sampling all the possible conformation, it would require a time equivalent to the age of universe to attain its native conformation.
Paradox is most small fold of protein which fold in fraction of time, say milisecond or microsecond
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