According to Wikipedia, Naproxen (an over-the-counter pain medication) is prepar

Question

According to Wikipedia, Naproxen (an over-the-counter pain medication) is prepared in 6 steps. In the
last step, the racemate is “resolved” (separated) into the enantiomers with a chiral amine (see below).
Part a) Describe how this process works.

2. According to Wikipedia, Naproxen (an over-the-counter pain medication) is prepared in 6 steps. In the last step, the racemate is "resolved" (separated) into the enantiomers with a chiral amine (see below) Part a) Describe how this process works. chiral amine specific rotation- CO2H +64° (S)-Naproxen racemiC Part b. If after the last step, the measured rotation of this compound is -16°, what is the ratio of enantiomers of this sample? %R = %s-

Explanation / Answer

Part a)

this process is called resolution

when it react chiral amine it will amide that is diastereomeric in nature because it with both isomers and give the two different diastereomers

once it became a diastereomer their physical properties will change like polarity, boling point , melting point, crstaloization charecter we can separate besed on this any property

suppose bith diastereomers are in different in polarity we can separate using cplumn chromato graphy

once you separate the both diastereomers ahanin you can hydrolyse the amide bond you will get the Narpoxene pure form of enantiomer

Part B no idea

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