According to Wikipedia, the Signal Recognition Particle (SRP) \"is a small, cyto

Question

According to Wikipedia, the Signal Recognition Particle (SRP) "is a small, cytosolic, highly conserved ribonucloprotein complex that recognizes proteins that are to be targeted to translation on the rough ER." That is, the Signal Recognition Particle recognizes the ER target tag and mediates translation on the ER. "Ribonucleoprotein" means that this particle is composed of both RNA and protein Although both SNP RNA genes and SNP protein genes are transcribed, the resulting transcripts are different in certain aspects. Which of the following comparisons between SNP RNA and SNP protein gene transcripts is correct? The transcript from the SNP RNA gene would complementary base pair with itself and with the transcript from the SNP protein gene. Transcripts from both SNP RNA and SNP protein genes may have introns spliced out. Transcripts from both SNP RNA and SNP protein genes would have a 5' cap. Transcripts from both the SNP RNA and SNP protein genes would be created in the nucleus but function in the cytoplasm. A. 1, 2 & 3 B. 1 & 3 C. 2 & 4 D. 4 only E. All of 1, 2, 3 & 4 are correct.

Explanation / Answer

Answer D) 4 only

Explanation - Here, we know that SRP (signal recognition particle) is a ribo-nucleoprotein complex which means it has a RNA domain and a protein domain which are complexed together to form a SRP complex. RNA domain is transcribed from the SRP RNA gene and the protein domain is transcribed from the SRP protein gene. all the SRP genes characterized so far do not have any introns in them (so the final options A, C and E must be incorrect). also, the SRP RNA gene is transcribed into the nucleus and it requires very limited processing only at the 3'-end (hence, the options A, B and E must be incorrect this way).

There's a formation of pre-SRP complex inside the nucleus where SRP RNA and SRP proteins are bound together to form a pre-SRP complex. this pre-SRP complex is released into the cytoplasm and become functional upon binding of remaining SRP components such as SRP54.

therefore, we can state that transcript from both the SRP RNA and SNP protein genes would be created in the nucleus but function in cytoplasm.

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