A) At pH 7.6, the curve is shifted to the left of the pH 7.4 curve because . . .

Question

A) At pH 7.6, the curve is shifted to the left of the pH 7.4 curve because . . .

B) What does HHb represent?

C) According to equilibrium binding equation above, O2 is released in tissues at pH 7.2 because:

reat importance nd release in the O O O Hemoglobin affinity for O2 is increased Hemoglobin affinity for O2 is decreased The curve shifts because there is more O2 in the lungs than in the tissues of the total H the tissues to the r of the H is ate buffer; the dissolved HCO3 CO2 is inversely he relatively low eripheral tissues, decreases as H d to the tissues lung, as CO, is uently rises, the creases and the to the peripheral centration on the oglobin is called ohr, the Danish Niels Bohr) whoblood is 7.6 in the lungs and 7.2 in the tissues. Experimental measure The binding equilibrium for H and O2 to Hb is (see text pg 170) pH 7.6 B) What does HHb represenit Hb with O Hb with a single positive charge on the whole molecule A protonated form of Hb, referring specifically to positively charged His146 residues in the Asubunits Hb with a positively charged heme group Protonation of all the amino terminal a-amino groups 0.5 pH 7.4 O O pH 7.2 C) According to equilibrium binding equation above, O2 is released in tissues at pH 7.2 because O The [H'1 is increased and the reaction shifts to the right, increasing HbO2 and H O The [H'] is decreased and the reaction shifts to the left, increasing HHb' and O2 O The [H'] is increased and the reaction shifts to the left, increasing HHb' and O2 O The [H] is decreased and the reaction shifts to the right, increasing HbO, and H 0 0 4 6 10 pO2 (kPa) FIGURE 5-16 Effect of pH on oxygen binding to hemoglobin. The pH of Previous & Give Up & View Solution e Check Answer Next ments on hemoglobin binding are often performed at pH 7.4

Explanation / Answer

A)

The normal pH of the blood plasma is 7.4. At high or low pH than normal the curve shifts from original location. Thus, at low pH 7.2 the curve shifts to right, while at pH 7.6 the curve shifts to left. With the decrease in pH the affinity of oxygen to hemoglobin decreases. In contrast, the increase in pH increases the affinity between the oxygen and hemoglobin. This is because at low pH the hydrogen ions increasingly bind to hemoglobin and decrease the affinity between oxygen and hemoglobin.

Hence, the correct option among the following is 1st one.

B)

The acidity is the determining factor in hemoglobin’s oxygen affinity. The HHb+ represents the protonated form of hemoglobin. It is specifically positively charged at His146 residues in beta subunits.

Hence, the correct option among the following is 2nd one.

C)

With the decrease in pH (7.2) from normal blood pH (7.4) the affinity of oxygen to hemoglobin decreases. This is because at low pH the hydrogen ions increasingly bind to hemoglobin and decrease the affinity between oxygen and hemoglobin.

Hence, the correct option among the following is 3rd one.

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