MDR1 is an ABC transporter. Describe its mechanism for transporting molecules ac
ID: 88785 • Letter: M
Question
MDR1 is an ABC transporter. Describe its mechanism for transporting molecules across the plasma membrane and the direction of transport. Identify another medically relevant protein in ABC transporter family. What does it transport? MDR1 is an ABC transporter. Describe its mechanism for transporting molecules across the plasma membrane and the direction of transport. Identify another medically relevant protein in ABC transporter family. What does it transport? Identify another medically relevant protein in ABC transporter family. What does it transport?Explanation / Answer
Answer= mechanism of transport of molecules across the plasma membrane by MDR 1
MDR1 is multidrug resistance protein 1 that pumps many foreign substances out of cells.
it is ATP dependent efflux pump with broad substrate specificity
it is efflux pump of xenobiotic compounds it transports various substrates across the cell membrane out of cell such as Drugs such as colchicine,tacrolimus ,chemotherapeutic agents ,lipids,steroids ,peptides ,bilirubin etc
another relevent protein in ABC transporter family is multidrug resistance protein MRP
MRP 1 ,MRP2 ,MRP3,MRP4,MRP5,MRP6
MRPs transport anticancer drugs
MRP1,2,3&5 are able to transport glutathione conjugates such as dinitrophenyl glutathione
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