Genetics. A series of 10 skin cell lines was grown from different XP (Xeroderma

Question

Genetics. A series of 10 skin cell lines was grown from different XP (Xeroderma pigmentosum- a type of skin cancer caused by loss of uV DNA damage repair). Cells from the lines were fused and the heterokaryotes (both nuclei present-think of this as a heterozygote for now) were tested for the ability to repair DNA damaged caused by a moderate amount of uV exposure. In the table below + indicates that the fusion cell lines performed normal DNA repair and - indicates defective DNA repair, a. From the information below, how many DNA-repair genes are mutated in the 10 cell lines, and b. identify which cell lines share the same mutated gene.

Explanation / Answer

a) 9 DNA repair genes are mutated in the 10 cell lines.

b) The following cell lines share the same mutated gene

1-3

1-7

2-5

2-6

2-10

3-7

4-8

5-6

5-10

6-10

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