In contrast to your new T2R, the Kd of the known TAS2R quinine receptor is 300 n

Question

In contrast to your new T2R, the Kd of the known TAS2R quinine receptor is 300 n. You discover that your new T2R gene is expressed predominantly in an indigenous population in Australia where the local diet includes a unique species of fruit. This fruit is highly nutritious, although it has a non-toxic level of quinine of approximately 5 n, but there is a closely related species of fruit that looks similar but contains a number of toxic compounds, including a quinine content of approximately 30 n. Provide a reason why

Explanation / Answer

The Kd of the known TAS2R Is 300nm which implies that the affinity of the TAS2R gene for quinine is quiet low. This implies, that when the concentration of quinine would be 300nM, the receptor will show affinity to the molecule. The new fruit discovered has a very low concentration of quinine which is approximately 5nM , whereas the old fruit had a much higher concentration of quinine. This implies that the new T2R is more favourable and found as a response to the new fruit species with a higher affinity of quinine so that even every low concentrations of quinine can be identified by this receptor. A closely related species has higher concentrations of quinine . This difference between the two species in the concentration of quinine might be due to the genes and expression of the proteins in the two species.

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