Genetics majors only please! This is one single question not separate ones Besid

Question

Genetics majors only please! This is one single question not separate ones

Beside each statement write either "none, mild, or severe" based on the degree of severity of effects on proteins.
A) a point mutation within an intron B) a point mutation in an intron splice site C) a missense mutation at a key conformational location D)a frameshift mutation very near the end of a gene E) a nonsense mutation at the beginning of a gene F) a synonymous mutation in an Exon
Genetics majors only please! This is one single question not separate ones

Beside each statement write either "none, mild, or severe" based on the degree of severity of effects on proteins.
A) a point mutation within an intron B) a point mutation in an intron splice site C) a missense mutation at a key conformational location D)a frameshift mutation very near the end of a gene E) a nonsense mutation at the beginning of a gene F) a synonymous mutation in an Exon
This is one single question not separate ones

Beside each statement write either "none, mild, or severe" based on the degree of severity of effects on proteins.
A) a point mutation within an intron B) a point mutation in an intron splice site C) a missense mutation at a key conformational location D)a frameshift mutation very near the end of a gene E) a nonsense mutation at the beginning of a gene F) a synonymous mutation in an Exon

Explanation / Answer

Explanation: Proein are encoded by the nucleotides present on the nucleic acids (DNA/RNA). Three nucleotides code (triplet codon) for single amino acid. each codon code for only one aminoacid. Each amino acid code by one or more than one codon.

A. None. Point mutation means change in single nucleotide (Means purine (A/G) replace with purine (G/A) or pyramidine (T/C). So it changes the codon. If codon changes, amino acid will change in protein. If mutation occured in intronic region (noncoding region), introns are not part of expressed gene and introns are removed through splicing mechanism in eukaryotes. so if mutation in intronic regoin not showed any siginificant effect on protein.

B. Severe. Point muatation in intron splice site, affect the splicing mechanism. Splicing is mediated by spliceosome. It acts on GU and AG of Introns. If point mutation ocuured at this point,introns not removed completely. It severely effect the functional protein.

C. Mild. Missense mutation means single nucleotide change in codon, so amino acid change will ocuured. It may change the confirmation of protein. Mainly it depend upon the replaced aminoacid. If basic aminoacid change to basic amino acid affect will be mild. It depend upon the replaced amino acid.

D. Mild. Frameshif mutation means chnage in the reading of codons. Insertion / deletion of single nucleotide will change the amino acid sequence. If it in end, not showed that significant affect.

E. Severe. Non sense mutation means codon convert into stop codon. If it occured at begining, protein synthesis terminated intially. So no protein.

F. None. Synonymous mutation means, mutation cause change in the codon but changed codon also code for same aminiacid. means no change in aminoacid sequence. So no affect.

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