Which of the following elements about nuclear transport of proteins is not true?

Question

Which of the following elements about nuclear transport of proteins is not true? A) Proteins are unfolded before being transported into the nucleus B) GTP bound Ran GTPase binds the import receptor in the nucleus C) Nuclear transport requires a nuclear localization signal on the cargo protein D) Proteins are transported through the nuclear pore complex In cells mutant for the gene nofuse, vesicles are seen budding off from the trans-Golgi network fuse with target membranes. Which of the following proteins does nofuse likely code for? A) Dynamin B) COP I C) V-SNARE D) Adaptin Which of the following statements about microtubule growth in cells is false? A) Microtubule growth is dependent on the y-tubulin ring complex B) GTP bound a and b tubulin dimers add on to the minus ends of microtubules C) Microtubules undergo dynamin instability D) Microtubules are stabilized by being captured at the cells cortex Which of the following types of intermediate filaments is found in epithelia? A) Lamins B) Keratin C) Vimentin D) Neuro filaments Which of the following is not a cellular function of microtubules A) Organelle positioning B) Movement of cilia C) Transport of vesicles D) Strengthening of the axon Which of the following proteins allow cells to adhere to collagen? A) Laminin B) Fibronectin C) Integrin D) Integrin and laminin E) Integrin and fibronectin

Explanation / Answer

Answer:

1) Which of the following elements about nuclear transport of proteins is not true?

A) Proteins are unfolded before being transported in the nucleus - FALSE (proteins are transported through nuclear pores in their fully folded conformation state)

B) GTP bound Ran GTPase binds the import receptor in the nucleus

C) Nuclear transport requires a nuclear localization signal on the cargo protein

D) Proteins are transported through the nuclear pore complex

2) In cells mutant for the gene nofuse, vesicles are seen budding off from the trans-Golgi network fuse with target membranes. Which of the following proteins does nofuse likely code for?

A) Dynamin - Correct

B) COP I

C) V-SNARE

D) Adaptin

3) Which of the following statements about microtubule growth in cells is false?

A) Microtubule growth is dependent on the y-tubulin ring complex

B) GTP bound a and b tubulin dimers add on to the minus ends microtubules - FALSE (GTP bound alpha and beta tubulin dimers assemble on to the plus (+) ends of microtubles)

C) Microtubules undergo dynamin instability

D) Microtubules are stabilized by being captured at the cells cortex

4) Which of the following types of intermediate filaments is found in epithelia?

A) Lamins

B) Keratin - Correct Answer (epithelia contains Keratin filaments in abundance that helps form the cytoskeletal network)

C) Vimentin

D) Neurofilaments

5) Which the following is not a cellular function of microtubules of

A) Positioning (correct - microtubles help in positioning organelles within the cytoplasm)

B) Movement of cilia (correct - microtubules help in cell movement by cilia and flagella)

C) Transport of vesicles (correct - microtubules play an active role in transport of organelles and vesicles intracellularly)

D) Strengthening of the axon - Incorrect

6) Which of the following proteins allow cells to adhere to collagen?

A) Laminin

B) Fibronectin

C) Integrin

D) Integrin and laminin

E) Integrin and Fibronectin - Correct

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