For questions 25-31, match the antibody isotype below with the related descripti

Question

For questions 25-31, match the antibody isotype below with the related description. Note, some may be used more than once. A. IgA B. IgG C. IgM D. IgD E. IgE Expressed on the surface of B cells earliest in maturation This is the only isotype to cross the placenta and protect the developing fetus Protects mucosal surfaces in the body as a dimer Attaches to the Fe receptors of mast cells and basophils This antibody is the first made during primary infection This antibody is found in a pentameric structure The most abundant class of antibodies in the serum *For questions 32-40, select which type of immunologic defect causes that condition. Immunologic Defects: A. Type I Hypersensitivity B. Type II Hypersensitivity C. Type III Hypersensitivity D. Type IV Hypersensitivity E. Autoimmunity AB. Primary Immunodeficiency AC. Secondary Immunodeficiency Conditions: Aggamaglobulinemia Immune complexes building up and causing arthritis (joint pain) Skin reaction to poison oak exposure Rheumatoid arthritis Breaking out in hives Blood transfusion reaction Selective IgA deficiency Systemic lupus erythematosis SCID

Explanation / Answer

25) Expressed on the surface of B cell earliest in maturation is IgM. The immature B cells are produced in the bone marrow. During the early maturation stage IgM is expressed on the surface of B cells. B cell development takes place after a series of process and when the B cell receptor, on the surface of the cell matches the detected antigens the B cell proliferates and secretes a free form of those receptors. After activation, the cell proliferates and B memory cells would form to recognize the same antigen.

26) This is the only isotype to cross the placenta and protect the developing fetus is IgG. Transfer of maternal IgG to the placenta is very important for the protection of the infant because they cannot produce their humoral response. And IgG is the only antibody to significantly cross the human placenta.

27) Protects mucosal surface in the body as a dimer is IgA. It is secreted into mucosal surfaces, such as the gut, respiratory tract, and urogenital tract, and it prevents the mucosal invasion into the body by pathogens. It is resistant to the proteolytic enzymes found in the gastrointestinal mucosa.

28) Attaches to the Fc receptors of mast cells and basophils is IgE. Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions.

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