List the reactions (enzyme names) in the citric acid cycle where: a. CO2 is rele

Question

List the reactions (enzyme names) in the citric acid cycle where:

a. CO2 is released

b. NADH is released

c. FADH2 is made

d. GTP is made

What is the only protein complex that is membrane bound in the TCA? (important to

remember when we get to oxidative phosphorylation.)

2. List the enzymes that serve as the major regulatory points for the citric acid cycle.

3. What impact does each of the following conditions have on flux through the citric acid cycle?

(a) high NADH/NAD+ ratio

(b) high ATP /ADP ratio

(c) high acetyl-CoA concentration

(d) low citrate concentration

(e) high succinyl-CoA concentration.

Explanation / Answer

1.?-Ketoglutarate dehydrogenase enzyme used

b Isocitrate +

NAD+------->>.Oxalosuccinate+

NADH + H +

Enzyme name Isocitrate dehydrogenase

c.Succinate dehydrogenase enzyme used

FAD?FADH2 in the first step of the reaction

d Succinyl-CoA +

GDP + Pi------.>>Succinate +
CoA-SH +
GTP

Enzyme name :- Succinyl-CoA synthetase

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