1) For motor proteins the work that can be done is equal to the displacement or
ID: 815859 • Letter: 1
Question
1) For motor proteins the work that can be done is equal to the displacement or powerstroke multiplied by the force against which the motor is working. There are limits to extending the lever arm of myosin assuming that the chemical energy to drive the movement is the hydrolysis of 1 ATP.
A) Calculate the free energy of ATP hydrolysis in a muscle cell. The standard free energy of ATP hydrolysis is -7.3 kcal/mol. Imagine that the cell is somewhat fatigued and [ATP] = 1mM, [ADP]=10?M and [Pi]=20mM. Temperature is 25
Explanation / Answer
A) delta G=Go + RTlnKeq (at 25oC, RT=0.529kcal/mol)
whwere Keq= [ADP] [Pi] /[ATP]
=10X20/1= 200mM
thus, delta G= -7.3 + 0.529 ln(200)
= -7.3 + 2.808
=-4.49kcal/mol.
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