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Leuprolide is a synthetic nonapeptide with the following structure. Note that th

ID: 814996 • Letter: L

Question

Leuprolide is a synthetic nonapeptide with the following structure. Note that the side chain of the N-terminal residue has formed a lactam with the N-terminal amino group. Which amino acid is in the D configuration (enter the name or 'none')? What is the amino acid sequence of this peptide? Enter your answer using the single letter abbretiavions for the amino acids; i.e. GPT, not Gly-Pro-Thr. Do not use spaces or hyphens. What is the net charge of this peptide at physiological pH? Enter your answer as a '0' or with a (+) or (-) sign and then an integer value; i.e. 0 or +1 or -2.

Explanation / Answer

amino acid sequence is GHTSTLLAP

at physiological pH it is negatively charged