(e) (2 points) Researchers report that there is low or no expression of MHC on t
ID: 79593 • Letter: #
Question
(e) (2 points) Researchers report that there is low or no expression of MHC on tumor cells. They find that treating the cells with HDAC inhibitors can restore expression of MHC on the surface of the tumor cells. What does this suggest about the regulation of the MHC genes in the tumor cells? (f (2 points) Put forth a hypothesis as to why down regulation of MHC expression might be relevant in progression of this disease. (g) (6 points) Why would it be useful to compare the gene expression from the two DFT types? Describe what experimental approach you would take to look at gene expression and what control(s) you would runExplanation / Answer
Answer:
3.a) Homozygous SNPs are the ones where both homologous chromosomes of the non-reference genome have the same allele and different from the reference genome.All the DFT2 sequences are matching with the reference sequences or with the alternate sequence.
3.b)A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 2–5 base pairs) are repeated, typically 5–50 times.Microsatellites occur at thousands of locations within an organism's genome; additionally, they have a higher mutation rate than other areas of DNA leading to high genetic diversity.Microsatellites can be used as markers in genetic studies of linkage in families and linkage disequilibrium studies of populations. In linkage studies one can examine large numbers or a large number of families and see when the alleles of specific markers are inherited together with a phenotype in more cases than not. Microsatellite repeats are amplified with fluorescent labelled primers and then the alleles from each individual in a family are separated by size and the marker tested for linkage with another.
3.c)Most of the SNPs are heterozygous or homozygous(reference), homozygous (alternate) is rare.There is quite high similarity between the unralated devil and DFT2 sequence.
3.d)DFT1- Sahal*32, Sahal *35, Sahal *46,Sahal *27, Sahal *90, Sahal *98,Sahal *45
DFT1-Sahal*32, Sahal *88, Sahal *35,Sahal *27, Sahal *90
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