1. We can estimate the entropy change when a 100 amino acid protein goes from an

Question

1.     We can estimate the entropy change when a 100 amino acid protein goes from an unfolded to a folded state. This protein follows these rules:

                        i.         each amino acid can have 5 possible conformers

                       ii.         the conformation of each residue is independent of the conformation of all others.

                     iii.         the folded state has a unique conformation.

Compute:

a.     How many conformations can this protein adopt?

b.     How many conformations are unfolded?

c.     What is the change in entropy for the folding process? (Hint: remember Boltzmann!)

We can estimate the entropy change when a 100 amino acid protein goes from an unfolded to a folded state. This protein follows these rules: each amino acid can have 5 possible conformers the conformation of each residue is independent of the conformation of all others. the folded state has a unique conformation. Compute: How many conformations can this protein adopt? How many conformations are unfolded? What is the change in entropy for the folding process? (Hint: remember Boltzmann!)

Explanation / Answer

a) 100P5 ( permutation)

b)

c) entropy will decrease in the folding process, as disoderness is decreasing

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.