A woman and a man have the same mutation in a gene on the X chromosome, which le

Question

A woman and a man have the same mutation in a gene on the X chromosome, which leads to no protein product being made from this gene. Each of them has one copy of this mutation. How would a biologist: A. explain how this mutation could affect the woman? B. explain how this mutation could affect the man? 2. A child is born with two X chromosomes and one Y chromosome. How would a biologist describe the different possible ways this could have happened during the production of sperm and/or egg by the child's parents?

Explanation / Answer

1. First question basics are that men are having XY chromosome while females are having XX chromosome. When we see a mutation have struck both of them in their X chromosome, they certainly not producing that gene product.

A. Firstly in case of women if the genetic information passes through as one X from mother and one X from father, the progeny cells is having the same defective X chromosome, then a critical function like Hemophilia A, a blood clotting disorder caused by a mutation of the Factor VIII gene.

B. Secondly we can see that a men could be affected as one X chromosome comes from mother, let’s say the defective one and another chromosome as Y from father, so still the male is having the chances carrying that defect, IN case we are experiencing Red-green color blindness, a X-lined disorder, the male will be affected.

2. If a could would born with a defect as having in its cell internally two X chromosome and one Y chromosome, a biologist like us have to comment on how the process have taken place. Biologically we know that there is disease named Klinefelter syndrome, results from such genetic condition, (47,XXY).

This is not an inherited disorder, but as a biologist we can show the process happens as, when the cell is dividing through meiosis stage of cell division, we have a process known as crossing over, there is an incorporation from a nondisjunction event during paternal or maternal meiosis I (gametogenesis). In karyotypic analysis we found it to be as XXY, as one more chromosome incorporation. Nondisjunction the X and Y or two X sex chromosomes, fail to separate. Klinefelter is even very common as Fertilizing a normal (X) egg with this sperm.

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